1998•Molecular PharmacologyRequires access

J-104,871, a Novel Farnesyltransferase Inhibitor, Blocks Ras Farnesylation In Vivo in a Farnesyl Pyrophosphate-Competitive Manner

Mari Yonemoto, Toshihiko Satoh, Hiroharu Arakawa, Ikuko Suzuki‐Takahashi, Yoshiaki Monden, Tsutomu Kodera, Kenji Tanaka, Tetsuya Aoyama, Yoshikazu Iwasawa, Toshio Kamei, Susumu Nishimura, Koji Tomimoto

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Key concepts: Farnesyltransferase, Farnesyl pyrophosphate, Prenylation, Farnesyl-diphosphate farnesyltransferase, Farnesyltransferase inhibitor, Lovastatin, Biochemistry, Squalene