1975•Journal of Applied PhysiologyRequires access

Pulmonary diffusing capacity and capillary blood volume in aging dogs

Nicola Robinson, J. R. Gillespie

Abstract

Single-breath carbon monoxide diffusing capacity (DLco), pulmonary capillary blood volume (Vc), and membrane diffusing capacity (Dm) were measured in 24 beagle dogs aged 289-3,882 days. DLco and Vc were a function of age and alveolar volume (Va). Vc decreased with age resulting in changes in DLco. Changes in Vc may have been due to pulmonary morphological changes or to an exaggerated decrease in pulmonary blood flow in old dogs in response to 20-30 cmH-2O transpulmonary pressure. There was no age-related change in Dm.

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Key concepts: DLCO, Diffusing capacity, Pulmonary Diffusing Capacity, Beagle, Lung volumes, Pulmonary function testing, Internal medicine, Blood volume