2014•PubMedRequires access

Expression of heat shock protein 20 inversely correlated with tumor progression in patients with ovarian cancer.

Naian Qiao, Yanhui Zhu, Haiying Li, Zhongyu Qu, Zhichun Xiao

Abstract

OBJECTIVE: To investigate a possible correlation between expression levels of heat shock protein 20 (HSP20) and tumor progression in patients with ovarian cancer. MATERIALS AND METHODS: The study included 34 patients with ovarian cancer who were to undergo surgery, seven patients with ovarian carcinoid tumors, and five patients with normal ovaries as a control group. Ovarian tissues were obtained from patients by surgical resection and then analyzed by western blot. RESULTS: Expression levels of HSP20 were inversely correlated with the grade of malignancy. CONCLUSION: The present findings suggest that HSP20 may play a protective role against the progression of ovarian cancer. Thus, HSP20 may represent a new target for the prediction and treatment of ovarian cancer.

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Key concepts: Medicine, Ovarian cancer, Heat shock protein, Malignancy, Western blot, Oncology, Internal medicine, Tumor progression