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FORMULATION AND EVALUATION OF BUCCOADHESIVE BI-LAYER TABLET OF PROPRANOLOL HYDROCHLORIDE

Deelip Vishram Derle, Omkar Joshi, Ashish Pawar, Jatin Patel, Amol B. Jagadale

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Abstract

The purpose of the study was to formulate and evaluate mucoadhesive bi-layer buccal tablets of propranolol hydrochloride tablets using the bioadhesive polymers such as sodium alginate and carbopol 971 P along with ethyl cellulose as an impermeable backing layer. The tablets were evaluated for weight variation, thickness, hardness, friability, surface pH, mucoadhesive strength, swelling index, in vitro drug release. Tablets containing sodium alginate and carbopol 971 P in the ratio of 5:1 showed the maximum percentage of in vitro drug release without disintegration in 12 hours. The swelling index was proportional to sodium alginate content and inversely proportional to carbopol 971 P content. The surface pH of all tablets was found to be satisfactory, close to neutral pH; hence, no irritation would observe with these tablets. The mechanism of drug release was found to be zero-order kinetics.

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What this paper is about

The purpose of the study was to formulate and evaluate mucoadhesive bi-layer buccal tablets of propranolol hydrochloride tablets using the bioadhesive polymers such as sodium alginate and carbopol 971 P along with ethyl cellulose as an impermeable backing layer. The tablets were evaluated for weight variation, thickness, hardness, friability, surface pH, mucoadhesive strength, swelling index, in vitro drug release. Tablets containing sodium alginate and carbopol 971 P in the ratio of 5:1 showed the maximum percentage of in vitro drug release without disintegration in 12 hours. The swelling index was proportional to sodium alginate content and inversely proportional to carbopol 971 P content. The surface pH of all tablets was found to be satisfactory, close to neutral pH; hence, no irritation would observe with these tablets. The mechanism of drug release was found to be zero-order kinetics.

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Available abstract

The purpose of the study was to formulate and evaluate mucoadhesive bi-layer buccal tablets of propranolol hydrochloride tablets using the bioadhesive polymers such as sodium alginate and carbopol 971 P along with ethyl cellulose as an impermeable backing layer. The tablets were evaluated for weight variation, thickness, hardness, friability, surface pH, mucoadhesive strength, swelling index, in vitro drug release. Tablets containing sodium alginate and carbopol 971 P in the ratio of 5:1 showed the maximum percentage of in vitro drug release without disintegration in 12 hours. The swelling index was proportional to sodium alginate content and inversely proportional to carbopol 971 P content. The surface pH of all tablets was found to be satisfactory, close to neutral pH; hence, no irritation would observe with these tablets. The mechanism of drug release was found to be zero-order kinetics.

Key concepts: Friability, Bioadhesive, Ethyl cellulose, Swelling, Propranolol Hydrochloride, Chemistry, Chromatography, Buccal administration

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FORMULATION AND EVALUATION OF BUCCOADHESIVE BI-LAYER TABLET OF PROPRANOLOL HYDROCHLORIDE — Research Paper | ScholarLens