Correlation in between coronary artery disease severity and peripheral artery disease

Background: Platelets play an important role in the pathophysiology of coronary artery disease.Naive platelets are larger in size and have more reactivity than older platelets.So the Platelet indices including Mean Platelet Volume, Plateletcrit, and Platelet Distribution Width may emerge a marker of CAD.The aim of the study is to study the role of Platelet indices in patients with Acute Coronary Syndrome and to see whether increase in platelet indices is associated with increased risk of Acute Coronary Syndrome.Materials and methods: In the present study patients who presented to NIMS with Acute Coronary Syndromes including Acute STEMI, NSTEMI were included.Platelet indices calculated in all these patients at the time of admission through automated analyzers.The effect of Platelet indices in patients with ACS is studied and compared with age and sex matched controls.Results: In our study total of 53 patients with ACS were studied.In our study MPV did not show any statistically significant difference in patients with ACS.On the other hand there was a significant difference in PCT & PDW in patients with ACS.Patients with ACS have higher values of PCT&PDW when compared to age matched controls.Conclusion: Larger platelets are hemostatically more active and are a risk factor for developing coronary thrombosis and subsequent acute coronary event (Acute STEMI/NSTEMI).Patients with larger platelets can easily be identified during routine hematological analysis and could possibly benefit from preventive treatment.