2010•Journal of chemical and pharmaceutical researchRequires access

Synthesis and in vitro bioevaluation of 1,5-bis(5-substituted benzimidazole) alkanes as antileishmanial agents.

Mahesh Verma, Anil Bhandari, Rajeev Nema

Abstract

Some 1,5-bis(5-substituted benzimidazole)alkanes (4a-4f, 5a-5f & 6a-6d) were synthesized from 3a-3f substituted benzimidazole and screened towards in vitro antileishmanial activity profile. Some of compounds such as 4c, 5c, 6c & 6d displayed good antileishmanial activity.

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Key concepts: Benzimidazole, In vitro, Chemistry, Combinatorial chemistry, Stereochemistry, Biochemistry, Organic chemistry