ScholarLens Back to search
1985•Clinical Infectious DiseasesRequires access

Effect of Imipenem/Cilastatin on the Colonic Microflora

Carl Erik Nord, L Kager, Agneta Philipson, G Stiernstedt

Open publisher page 19 citations

Abstract

The effect of imipenem/cilastatin on the colonic microflora was investigated in 10 patients receiving the drug for six to 11 days. Fecal specimens were cultured quantitatively for aerobic and anaerobic microorganisms before, during, and after therapy. Imipenem/cilastatin treatment was associated with minor changes in the colonic flora. A small decrease in the numbers of enterobacteria, enterococci, anaerobic cocci, and organisms of the Bacteroides fragilis group was observed. After treatment was discontinued, the microflora returned to normal in all patients, and no new colonization with imipenem-resistant bacteria was seen. No patient had Clostridium difficile or its cytotoxin in feces. No adverse gastrointestinal reactions were registered.

About this research paper

What this paper is about

The effect of imipenem/cilastatin on the colonic microflora was investigated in 10 patients receiving the drug for six to 11 days. Fecal specimens were cultured quantitatively for aerobic and anaerobic microorganisms before, during, and after therapy. Imipenem/cilastatin treatment was associated with minor changes in the colonic flora. A small decrease in the numbers of enterobacteria, enterococci, anaerobic cocci, and organisms of the Bacteroides fragilis group was observed. After treatment was discontinued, the microflora returned to normal in all patients, and no new colonization with imipenem-resistant bacteria was seen. No patient had Clostridium difficile or its cytotoxin in feces. No adverse gastrointestinal reactions were registered.

Why it matters

OpenAlex reports 19 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The effect of imipenem/cilastatin on the colonic microflora was investigated in 10 patients receiving the drug for six to 11 days. Fecal specimens were cultured quantitatively for aerobic and anaerobic microorganisms before, during, and after therapy. Imipenem/cilastatin treatment was associated with minor changes in the colonic flora. A small decrease in the numbers of enterobacteria, enterococci, anaerobic cocci, and organisms of the Bacteroides fragilis group was observed. After treatment was discontinued, the microflora returned to normal in all patients, and no new colonization with imipenem-resistant bacteria was seen. No patient had Clostridium difficile or its cytotoxin in feces. No adverse gastrointestinal reactions were registered.

Key concepts: Medicine, Imipenem/cilastatin, Cilastatin, Imipenem, Internal medicine, Microbiology, Antibiotics, Antibiotic resistance

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effect of Imipenem/Cilastatin on the Colonic Microflora — Research Paper | ScholarLens