1982•Annals of Clinical Biochemistry International Journal of Laboratory MedicineRequires access
Influence of Pyridoxal-5′-Phosphate on Temperature Relationship of Aspartate Aminotransferase and Alanine Aminotransferase
Jan C. M. Hafkenscheid, Johanna van der Ven‐Jongekrijg, TH. De Boo
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Abstract
The influence of pyridoxal-5'-phosphate on the temperature relationship of aspartate aminotransferase and alanine aminotransferase has been determined. On varying the reaction temperature from 25 degrees to 45 degrees both enzymes showed small but significant deviations from a linear Arrhenius relationship. Supplementation with pyridoxal-5'-phosphate in general enhanced the catalytic activity to the same degree over the entire temperature range. Our results corroborate the findings of Rej but not those of Jung et al.