Metabolism, in the Rat, of Biotin Injected Intraperitoneally as the Avidin-Biotin Complex

Radioactive biotin injected intraperitoneally into rats as the avidin complex was found to be excreted much more slowly than the free vitamin. However, the biotin-avidin complex is dissociated in vivo and the released biotin both excreted and metabolized to sulfoxides and bisnorbiotin as is free biotin. That liver has the capacity to cause dissociation of the avidin-biotin complex, as well as metabolize the vitamin, was also demonstrated.