Fibrinolysis II: Absence of Antibodies to Streptokinase Following Injection of Purified Human Plasmin in Rabbits.

The results with the agar precipitation technic indicated the existence of multiple antigenic constituents of human plasmin, possibly due to contamination by other components of plasma. Our preparations of human plasmin. however, either contained no streptokinase or amounts of this agent insufficient to induce an antigenic response. Streptokinase represents a possible contaminant or constituent of plasmin. Thus, at least in our experimental condition, negative results are important as they eliminate one possible source of iso-antigenicity of human plasmin.