Weaning Strategies in Problem Patients

Weaning usually accounts for approximately 40–50% of the total duration of mechanical ventilation. Approximately two-thirds of patients can tolerate withdrawal of ventilation without the need for more gradual weaning, but there are a significant number of patients for whom weaning is difficult. Weaning failure is defined as the failure of a spontaneous breathing trial, or the need for re-intubation within 48 hours of extubation. This article reviews the causes of failure to wean, and outlines a practical approach to dealing with the difficult-to-wean patient. The key to successful weaning combines an approach which optimises ventilation at night, adopts a stepwise approach to reducing ventilatory dependence during the day, and uses non-invasive ventilation as a ‘bridge’ out of the ICU. Having a weaning protocol and ensuring it is initiated in a timely manner is likely to be as important as what is in the protocol.