II. Effects of Sulfanilamide and Sulfapyridine upon Experimental Streptococcal Infections

The method here presented appears satisfactory for -chemotherapeutic investigation. The beneficial therapeutic effect of both sulfanilamide and sulfapyridine on hemolytic streptococcal infection in white mice and hamsters is presented. Sulfapyridine is definitely superior to sulfanilamide in that it is less toxic. A very large dose of sulfapyridine can be given at one time to sterilize the infection without producing any toxic symptoms. These experiments also indicated the prompt penetration of the drug into the brain tissue.