1974•Experimental Biology and MedicineRequires access
Inhibition of Cellular Immune Reactions by Cyclophosphamide Analogues Ifosfamide and Trofosfamide. I. Mixed Lymphocyte Reaction
R. G. Devlin, Nira Schwartz, P. E. Baronowsky
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Abstract
The cyclophosphamide analogues ifosfamide and trofosfamide suppressed the mixed lymphocyte reaction in mice to about the same extent as did cyclophosphamide when the dose of the three drugs was 100 mg/kg intraperitoneally. The suppressive activity of ifosfamide was dose dependent, and the ED50 dose was 62 mg/kg intraperitoneally, twice that of cyclophosphamide. The activity of trofosfamide was not adequately dose dependent.