Possible use of tape formulation containing glyceryl monocaprylate and dopamine hydrochloride.

Several tape formulations containing a possible drug, dopamine hydrochloride and a useful penetration-enhancer, glyceryl monocaprylate were prepared, and the release rate and skin permeation rate were measured. Skin permeation was measured in vitro by using the excised hairless rat skin and diffusion cell. Release rate from the drug-suspended adhesive was rapider than that from the drug-dissolved one. Acrylvinyl-type adhesive showed the best skin permeation of the drug among the adhesives tested in the present study. The higher were the drug concentration and enhancer concentration, the higher was the skin permeation. The blood concentration after application the formulation could be predicted by the in vitro skin permeation data and elimination pharmacokinetics.