1989•日本歯周病学会会誌Requires access
The effects of anti-Bacteroides gingivalis(Bg), and anti-Actinobacillus actinomycetemcomitans(Aa) antibodies on Bg and Aa.
Kazuhito HORINO, Keiichi Satoh, Hiromasa Yoshie, Kohji Hara
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Abstract
The purpose of this study was to determine the effects of anti-Bacteroides gingivalis (Bg) and anti-Actinobacillus actinomycetemcomitans (Aa) antibodies on Bg and Aa respectively. Bg and Aa were resistant to complement-mediated bactericidal activity, and killing by PMN. However a significant reduction in CFU of Bg and Aa was found when these bacteria were incubated with the antibodies and not agitated. This would suggest that the antibody was capable of aggregating or phagocytizing, but not killing, these bacteria when complement and PMN were added. Moreover the antibodies had no effect on bacterial proliferation. Anti Aa antibody also had no effects on killing of Aa or PMN infiltration in experimentally established periodontal pockets in dogs.