2000•Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)Open access
EXPRESSION OF LAMININ AND CADHERIN ASSOCIATED WITH LIVER METASTASIS IN HUMAN COLORECTAL CANCER -AN APPROACH FROM IMMUNOHISTOCHEMISTRY-
Masaichi Ogawa, Kenji Ikeuchi, Michiaki Watanabe, Yasushi Kaneko, Ken Etoh, Toru Fujikawa, Yoshihiko Takao, Sadao Anazawa, Yoji Yamazaki
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Abstract
The significance of laminin and cadherin expression in human colorectal cancer was investigated by immunohistochemical assay, and its correlation with liver metastasis was analyzed. In the synchronous metastasis group, 17 of 34 cases (50%) showed positive staining of laminin, 14 (41%) of cadherin, and 5 (14%) a decreased rate of cadherin. In the metachronous metastasis group, 17 of 30 (57%) showed positive staining of laminin, 12 (40%) of cadherin, and 6 (20%) a decreased rate of cadherin. In a control group (free of disease for 5 years), in spite of no significant differences in clinicopathological factors compared with the other two groups, only 2 of 37 cases (5%) showed positive staining of laminin, 8 (22%) in cadherin, and 2 (5%) a decreased rate of cadherin. Thus, the metastatic groups were significantly higher than the control group in expression of laminin, but no significant difference in expression of cadherin was observed. These findings suggest that laminin is a useful parameter for predicting liver metastasis.
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