STUDIES ON ALLERGIC CONJUNCTIVITIS

Allergic coujunctivitis was experimentally induced in male albino guinea pigs by applying to the eye pollen of Pinus Thumbergii as sensitizing antigen, with the following results : 1) At 50-70 days of observation, chief infiltrating cells were neutrophils, lymphocytes and plasmocytes. Cellular infiltration was most intense in a group which received first the sensitizing and later the provoking application, followed by a group which received the two applications simutaneously, and a group which received only one application.2) Examination of the times of two succeeding applications revealed that the appearance of neutrophils, lymphocytes and plasmocytes was independent from the time of the first and later application.3) The descending order of intensity of cellular infiltration and epithelial proliferation in various parts of the conjunctiva was limbus corneae, conjunctiva tarsi, conjunctiva fornici, and conjunctiva bulbi. This is the same as in allergic conjunctivitis such as phlyctaen and conjunctiviuis vernalis.