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Serum amyloid-A protein concentration in rheumatic disease.

Megumu Higaki, Tsugiko Takase, Michiko Tatsuno, Keiko Hoshi, Yutaka Mizushima

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Abstract

The serum concentration of serum amyloid-A protein (SAA) and C-reactive protein (CRP) as the acute phase proteins have been measured in 56 patients with rheumatoid arthritis (RA), 18 with systemic lupus erythematosus (SLE), and 18 with Behcet's disease (BD) . In RA patients, SAA and CRP concentration correlated well (r=0.87), though SAA showed a greater incremental increase than CRP. In SLE and BD patients, SAA was raised in 37% of patients with normal CRP. These findings suggest that SAA is a more sensitive marker of inflammation than is CRP.

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The serum concentration of serum amyloid-A protein (SAA) and C-reactive protein (CRP) as the acute phase proteins have been measured in 56 patients with rheumatoid arthritis (RA), 18 with systemic lupus erythematosus (SLE), and 18 with Behcet's disease (BD) . In RA patients, SAA and CRP concentration correlated well (r=0.87), though SAA showed a greater incremental increase than CRP. In SLE and BD patients, SAA was raised in 37% of patients with normal CRP. These findings suggest that SAA is a more sensitive marker of inflammation than is CRP.

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Available abstract

The serum concentration of serum amyloid-A protein (SAA) and C-reactive protein (CRP) as the acute phase proteins have been measured in 56 patients with rheumatoid arthritis (RA), 18 with systemic lupus erythematosus (SLE), and 18 with Behcet's disease (BD) . In RA patients, SAA and CRP concentration correlated well (r=0.87), though SAA showed a greater incremental increase than CRP. In SLE and BD patients, SAA was raised in 37% of patients with normal CRP. These findings suggest that SAA is a more sensitive marker of inflammation than is CRP.

Key concepts: Serum amyloid A, Serum Amyloid A Protein, Rheumatoid arthritis, C-reactive protein, Acute-phase protein, Medicine, Inflammation, Internal medicine

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