1985•Chemical and Pharmaceutical BulletinOpen access
Binding of glycyrrhizin to rat plasma and rat serum albumin.
Tsutomu Ichikawa, Shiro Ishida, Yoko Sakiya, Yasufumi Sawada
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Abstract
The binding of glycyrrhizin to rat plasma and rat serum albumin (RSA) was examined by using an ultrafiltration technique. Two classes of binding sites, primary and secondary, were observed in both plasma and RSA. It was concluded that the binding of glycyrrhizin to the primary binding sites mainly determines the plasma protein binding of the drug in rats.
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