1972•THE JOURNAL OF VITAMINOLOGYOpen access

Inhibition by Thiamine Phosphates of Thiamine Uptake in Escherichia coli

Atsuko Matsuura, Akio Iwashima, Yoshitsugu Nose

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Abstract

The uptake of thiamine in Escherichia coli was inhibited by thiamine phosphates. It was also demonstrated that the binding of thiamine to thiamine-binding protein, which is thought as a functional component in the transport system of thiamine, is markedly inhibited by thiamine phosphates.The possibility that thiamine and thiamine phosphates share a common transport system in Escherichia coli is discussed.

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The uptake of thiamine in Escherichia coli was inhibited by thiamine phosphates. It was also demonstrated that the binding of thiamine to thiamine-binding protein, which is thought as a functional component in the transport system of thiamine, is markedly inhibited by thiamine phosphates.The possibility that thiamine and thiamine phosphates share a common transport system in Escherichia coli is discussed.

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Available abstract

The uptake of thiamine in Escherichia coli was inhibited by thiamine phosphates. It was also demonstrated that the binding of thiamine to thiamine-binding protein, which is thought as a functional component in the transport system of thiamine, is markedly inhibited by thiamine phosphates.The possibility that thiamine and thiamine phosphates share a common transport system in Escherichia coli is discussed.

Key concepts: Thiamine, Escherichia coli, Chemistry, Biochemistry, Thiamine pyrophosphate, Thiamine deficiency, Enzyme, Cofactor

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