2000•Journal of the Korean Radiological SocietyRequires access
Outcome Evaluation of Intra-arterial Infusion of Urokinase for Acute Ischemic Stroke
Hai Bin Shi, Dae Chul Suh, Soo Mee Lim, Jae Hong Lee, Tae Yong Kim, Ae Kyung Jeong, Choong Gon Choi, Ho Kyu Lee, Tae Hwan Li
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Abstract
Pupose: To evaluate the results of intra-arterial urokinase thrombolysis in cases of acute ischemic stroke and to define the factors affecting prognosis. Materials and Methods: Forty-eight patients with angiographically proven occlusion of the intracranial arteries were treated with local intra-arterial infusion of urokinase within six hours of the onset of symptoms. Neurologic status was evaluated on admission and on discharge using the NIH(National Institute of Health) stroke scale score (SSS). When the SSS decreased by at least four points, this was considered indicative of an improved clinical outcome. Results: Complete recanalization was achieved in 17/48 patients (35%), including 8 of 13 (62%) with occlusion of the vertebrobasilar artery (VBA), 9 of 20 (45%) with occlusion of the middle cerebral artery (MCA), and none of 15 with occlusion of the internal carotid artery (ICA). Neurologic status improved in 12 (60%) of patients with MCA occlusion, in five (38%) of those with VBA occlusion and in three (20%) of those with ICA occlusion (P