2011•Practica Oto-Rhino-LaryngologicaRequires access

A Case of Hyperparathyroidism Following Acute Pancreatitis

Rei Matsumura, Kotetsu Lee, Shuji Nishikawa, Akihito Mineharu, Michitoshi Araki, Ryo Kawata

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Abstract

We report a case of 31-year-old man with acute pancreatitis associated with hypercalcemia as the first manifestation of primary hyperparathyroidism due to benign parathyroid adenoma. After initial, conservative treatment, intact PTH and serum calcium levels improved, which is followed by adenoma resection. Although parathyroid-adenoma-induced hypercalcemia is known to be associated with acute pancreatitis, the medical entity is very uncommon. The pathophysiology of hypercalcemia-induced acute pancreatitis is poorly understood despite proposed mechanisms. Because parathyroid adenoma with hypercalcemia is common, the relationship between hyperparathyroidism and pancreatitis or ossifying fibrosis requires better clarification.

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What this paper is about

We report a case of 31-year-old man with acute pancreatitis associated with hypercalcemia as the first manifestation of primary hyperparathyroidism due to benign parathyroid adenoma. After initial, conservative treatment, intact PTH and serum calcium levels improved, which is followed by adenoma resection. Although parathyroid-adenoma-induced hypercalcemia is known to be associated with acute pancreatitis, the medical entity is very uncommon. The pathophysiology of hypercalcemia-induced acute pancreatitis is poorly understood despite proposed mechanisms. Because parathyroid adenoma with hypercalcemia is common, the relationship between hyperparathyroidism and pancreatitis or ossifying fibrosis requires better clarification.

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Available abstract

We report a case of 31-year-old man with acute pancreatitis associated with hypercalcemia as the first manifestation of primary hyperparathyroidism due to benign parathyroid adenoma. After initial, conservative treatment, intact PTH and serum calcium levels improved, which is followed by adenoma resection. Although parathyroid-adenoma-induced hypercalcemia is known to be associated with acute pancreatitis, the medical entity is very uncommon. The pathophysiology of hypercalcemia-induced acute pancreatitis is poorly understood despite proposed mechanisms. Because parathyroid adenoma with hypercalcemia is common, the relationship between hyperparathyroidism and pancreatitis or ossifying fibrosis requires better clarification.

Key concepts: Medicine, Acute pancreatitis, Hyperparathyroidism, Parathyroid adenoma, Pancreatitis, Primary hyperparathyroidism, Adenoma, Pathophysiology

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