Influence of Spleen on Leucocyte Count of the Albino Rat

It is evident from the work described and the charts shown that in the Bartoiiella-free albino rat: 1. Following splenectomy, the total leucocyte count increases to 3 to 4 times normal. 2. This increase is due to a neutrophilia of a myeloid type which is more intense than that following other trauma. 3. Following a comparable surgical procedure, partial hysterectomy, the total leucocyte count increases to 1 ½ to 2 times normal. 4. This increase is due to a weak neutrophilia of a type that is usually found following surgical trauma. 5. Following spleen transplantation into a spleen-possessing rat, there appear to be no significant changes. 6. Following splenectomy, there is a lesser leucocytosis of a neutrophilic nature in the spleen transplant recipients than in the muscle transplant controls. 7. This leucocytosis approaches normal with greater rapidity in the spleen transplant recipients than in the controls. 8. Following removal of the spleen transplants, the blood picture resembles that following splenectomy, though in milder fashion. 9. Following removal of the muscle transplant sites, the blood picture indicates mild trauma. 10. Spleen homiotransplants may be 88% successful.