Amine Metabolism after an Overdose of a Monoamine Oxidase Inhibitor

SINCE iproniazid was shown to be an effective monoamine oxidase inhibitor by Zeller et al.1 in 1952 there has been extensive use of monoamine oxidase inhibitors, particularly in psychiatric diseases,2 angina pectoris3 and hypertension.4 The usual side effects of monoamine oxidase inhibitors, such as postural hypotension, dizziness and dryness of the mouth, are well known.5 , 6 With excessive doses, marked Central-nervous-system disturbances occur. The management of patients who have ingested an overdose of a monoamine oxidase inhibitor has not been well documented. The purpose of this paper is to report the clinical characteristics of a patient who ingested a large amount . . .