1978•Experimental Biology and MedicineRequires access

Stimulation of Growth Hormone Release by Intraventricular Administration of 5HT or Quipazine in Unanesthetized Male Rats

E. Vijayan, L. Krulich, Samuel M. McCann

Abstract

Intraventricular injection of 5HT (4 and 20 μg) in unanesthetized, unrestrained male rats fitted with permanent intrajugular cannulas for withdrawal of blood samples caused a dose-related elevation of plasma GH levels. Similar effects were also observed following intraventricular injection of the serotonin receptor agonist, quipazine. The GH-releasing effect of both drugs was abolished by a serotonin receptor blocker, methysergide. It is concluded that activation of the central serotoninergic system stimulates GH secretion in the rat.

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Key concepts: Quipazine, Methysergide, Endocrinology, Internal medicine, Serotonergic, Serotonin, 5-HT receptor, Agonist