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2015•Transplantation and Cellular TherapyOpen access

The Safety of Granulocyte Colony Stimulating Factor (G-CSF) Administration in Pediatric Donors before Peripheral Hematopoietic Stem Cell Donation

Amir Ali Hamidieh, Maryam Behfar, Sara Faghihi‐Kashani, Ashraf sadat Hosseini, Ardeshir Ghavamzadeh

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Abstract

Although administration of G-CSF to healthy donors for mobilization and collection of peripheral blood stem cell (PBSC) is common in adult volunteers, there are limited data on short-and especially long-term efficacy in healthy pediatric donors, notably due to ethical issues. The purpose of this study was to assess the short- and long-term adverse effects of using G-CSF in pediatric sibling donors.

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What this paper is about

Although administration of G-CSF to healthy donors for mobilization and collection of peripheral blood stem cell (PBSC) is common in adult volunteers, there are limited data on short-and especially long-term efficacy in healthy pediatric donors, notably due to ethical issues. The purpose of this study was to assess the short- and long-term adverse effects of using G-CSF in pediatric sibling donors.

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Available abstract

Although administration of G-CSF to healthy donors for mobilization and collection of peripheral blood stem cell (PBSC) is common in adult volunteers, there are limited data on short-and especially long-term efficacy in healthy pediatric donors, notably due to ethical issues. The purpose of this study was to assess the short- and long-term adverse effects of using G-CSF in pediatric sibling donors.

Key concepts: Medicine, Granulocyte colony-stimulating factor, Adverse effect, Peripheral blood, Haematopoiesis, Granulocyte, Stem cell, Donation

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