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Comparison of Antiarrhythmic Effects of Procainamide, N-Acetylprocainamide, and p-Hydroxy-N-(3-diethylaminopropyl)benzamide

R. D. Reynolds, William E. Burmeister, Samuel V. Calzadilla, R. J. Lee, M M Reidenberg, Dennis E. Drayer

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Abstract

The antiarrhythmic effects of p-hydroxy-N-(3-diethylaminopropyl)benzamide (PP), procainamide (PA), and N-acetylprocainamide (NAPA) were compared. ED50 values for PP, PA, and NAPA in the mouse chloroform arrhythmia model were not significantly different. Mean effective doses in the ouabain-intoxicated dog were: PP 34, PA 25, and NAPA 122 mg/kg. PP was effective in 3/5, PA in 5/6, and NAPA in 0/5 dogs at 24 hr after ligation of the left anterior descending coronary artery. Thus, PP has antiarrhythmic potency and efficacy intermediate to PA and NAPA.

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What this paper is about

The antiarrhythmic effects of p-hydroxy-N-(3-diethylaminopropyl)benzamide (PP), procainamide (PA), and N-acetylprocainamide (NAPA) were compared. ED50 values for PP, PA, and NAPA in the mouse chloroform arrhythmia model were not significantly different. Mean effective doses in the ouabain-intoxicated dog were: PP 34, PA 25, and NAPA 122 mg/kg. PP was effective in 3/5, PA in 5/6, and NAPA in 0/5 dogs at 24 hr after ligation of the left anterior descending coronary artery. Thus, PP has antiarrhythmic potency and efficacy intermediate to PA and NAPA.

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Available abstract

The antiarrhythmic effects of p-hydroxy-N-(3-diethylaminopropyl)benzamide (PP), procainamide (PA), and N-acetylprocainamide (NAPA) were compared. ED50 values for PP, PA, and NAPA in the mouse chloroform arrhythmia model were not significantly different. Mean effective doses in the ouabain-intoxicated dog were: PP 34, PA 25, and NAPA 122 mg/kg. PP was effective in 3/5, PA in 5/6, and NAPA in 0/5 dogs at 24 hr after ligation of the left anterior descending coronary artery. Thus, PP has antiarrhythmic potency and efficacy intermediate to PA and NAPA.

Key concepts: Procainamide, NAPA, Benzamide, ED50, Potency, Chemistry, Pharmacology, Internal medicine

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Comparison of Antiarrhythmic Effects of Procainamide, N-Acetylprocainamide, and p-Hydroxy-N-(3-diethylaminopropyl)benzamide — Research Paper | ScholarLens