Changing of Uric Acid Levels by Age and Sex in Patients with Diabetes Mellitus

Objective: We examined the association between uric acid and glycemic status by the aspects of age and sex. Methods: The retrospective was performed study at Okmeydanı Educate and Research Hospital. All data were obtained from the patient records. Only one sam­ple of HbA1c or glucose measurement within a year was included. To evaluate the pattern of glucose control, we categorized the patients according to HbA1c levels and grouped them according to a range of values. HbA1c was measured by high performance liquid chromatography, routine biochemistry parameters were determined by photometric method. Results: Serum uric acid levels showed an increasing trend with the age in female group and this trend became significant after 30 years old (p<0.001). The significant ef­fect of HbA1c and gender on uric acid levels were deter­mined in the subjects having no renal failure. There was a significant increase of uric acid levels in prediabetics than normal group and decrease in unregulated diabetics. But in both sex groups the pattern of changing was different. Conclusion: In conclusion, we found that age is an im­portant factor examining the serum uric acid levels of fe­male subjects. The peak values of serum uric acid were detected in prediabetic group in males but in females this peak point was diabetic group.