1971•Folia Endocrinologica JaponicaOpen access

Biological Activities of Deshistidine-glucagon

Yoshio Ikeda, Norio OBAYASHI, Hiroshi Saito, Yasuhiko Matsu-ura, Takashi Sano, Tomio Tanese

Abstract

GlucagonからN末端アミノ酸であるHistidineをとりのぞいたDeshistidine-glucagon (DH-glucagon) について, その生物活性を, in vivoとin vitroでNative-glucagonのそれと比較検討した.DH-91ucagonをラットの腹腔内に投与したさいの血糖上昇作用およびDH-91ucagonをin vitroに添加したさいの, ラット副睾丸脂肪組織へのブドウ糖のとりこみ, medium中へのGlycerol放出はGlucagonと比較して明らかに欠如した.このようにDH-glucagonにはGlucagonにみられるような活性の認められないことを示唆した.

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Key concepts: Glucagon, In vitro, Internal medicine, Chemistry, In vivo, Endocrinology, Biology, Biochemistry