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Effect of TJ-48 on murine cellular immunity.

Norito Takemoto, Hideki Kawamura, Hirofumi Maruyama, Yasuhiro Komatsu, Masaki Aburada, Eikichi Hosoya

Abstract

The effects of Juzentaihoto (TJ-48) on cellular immunity were investigated by using delayed type hypersensitivity (DTH) reaction, mixed lymphocyte culture response (MLR) and cytotoxic T lymphocyte (CTL) response. Oral administration of TJ-48 was found to induce the augmentation of DTH and CTL responses. TJ-48 tended to enhance the MLR although it was not statistically significant. These results suggest that TJ-48 has an immunopotentiating activity on cellular immunity in addition to humoral immunity which we have reported previcusly.

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Available abstract

Key concepts: CTL*, Cellular immunity, Immunity, Immunology, Humoral immunity, Cytotoxic T cell, Mixed lymphocyte reaction, T lymphocyte