1947•Experimental Biology and MedicineRequires access

Mitotic Response to Colchicine in Human Cancer.

M N Levine, Gary Silver

Abstract

1. These observations seem to indicate that a single intramuscular injection of 2 mg of colchicine induces an arrest of nuclear division in the metaphase stage of human cancer. The number of cells in this stage increases slowly and the effect reaches a maximum between the 16th and 24th hours. The decline in number of metaphases is more gradual than the rise.

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Available abstract

Key concepts: Colchicine, Metaphase, Mitosis, Cancer, Stage (stratigraphy), Biology, Andrology, Intramuscular injection