ScholarLens Back to search
1978•Experimental Biology and MedicineRequires access

Role of Manganese, Bilirubin and Sulfobromophthalein in Manganese-Bilirubin Cholestasis in Rats

Eve de Lamirande, Gàbriel L. Plaa

Open publisher page 19 citations

Abstract

Combination of noncholestatic doses of manganese and bilirubin produced a dramatic fall in bile flow. Furthermore the order and injection times were critical, suggesting that the manganese-bilirubin interaction is complex and proceeds via a shortlived intermediate pathway. Protection against cholestasis seems assured by BSP before its conjugation. Because the protection is abolished either by increasing the bilirubin dosage or lowering the BSP dosage a BSP-bilirubin interaction appears to be a possible mechanism for the protection seen in manganese-bilirubin cholestasis.

About this research paper

What this paper is about

Combination of noncholestatic doses of manganese and bilirubin produced a dramatic fall in bile flow. Furthermore the order and injection times were critical, suggesting that the manganese-bilirubin interaction is complex and proceeds via a shortlived intermediate pathway. Protection against cholestasis seems assured by BSP before its conjugation. Because the protection is abolished either by increasing the bilirubin dosage or lowering the BSP dosage a BSP-bilirubin interaction appears to be a possible mechanism for the protection seen in manganese-bilirubin cholestasis.

Why it matters

OpenAlex reports 19 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Combination of noncholestatic doses of manganese and bilirubin produced a dramatic fall in bile flow. Furthermore the order and injection times were critical, suggesting that the manganese-bilirubin interaction is complex and proceeds via a shortlived intermediate pathway. Protection against cholestasis seems assured by BSP before its conjugation. Because the protection is abolished either by increasing the bilirubin dosage or lowering the BSP dosage a BSP-bilirubin interaction appears to be a possible mechanism for the protection seen in manganese-bilirubin cholestasis.

Key concepts: Sulfobromophthalein, Bilirubin, Cholestasis, Manganese, Chemistry, Internal medicine, Biochemistry, Medicine

Related papers

Related paper 1Related paper 2
Back to paper searchBrowse research topicsOriginal source
Role of Manganese, Bilirubin and Sulfobromophthalein in Manganese-Bilirubin Cholestasis in Rats — Research Paper | ScholarLens