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EFFECTS OF AUTONOMIC BLOCKING AGENTS ON GASTRIC SECRETION AND ULCERATION INDUCED BY CINCHOPHEN

Hiroshi Sato

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Abstract

Effects of anticholinergic drugs on gastric secretin induced by cinchophen were investigated on dogs with total gastric pouch, and it was found out that Antrenyl, Pro-banthine and Tropin all strongly inhibited such secretion, but that a little larger doses than that of insulin were necessary ; effect of Banthine was rather inferior to the above. These anticholinergic drugs were not considered to exert any inhibitory action on the hypothalamic-pituitary-adrenocortical system, which is related to the gastric secretion by cinchophen, but to inhibit the release of the secretory substance into the stomach by acting on its glandular cells. Regitin and chlorpromazine did not show any inhibitory acticn on gastric secretion by cinchophen.Combined administrarion of cinchophen and Tropin for 3 weeks produced ulcer as in controls.

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Effects of anticholinergic drugs on gastric secretin induced by cinchophen were investigated on dogs with total gastric pouch, and it was found out that Antrenyl, Pro-banthine and Tropin all strongly inhibited such secretion, but that a little larger doses than that of insulin were necessary ; effect of Banthine was rather inferior to the above. These anticholinergic drugs were not considered to exert any inhibitory action on the hypothalamic-pituitary-adrenocortical system, which is related to the gastric secretion by cinchophen, but to inhibit the release of the secretory substance into the stomach by acting on its glandular cells. Regitin and chlorpromazine did not show any inhibitory acticn on gastric secretion by cinchophen.Combined administrarion of cinchophen and Tropin for 3 weeks produced ulcer as in controls.

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Available abstract

Effects of anticholinergic drugs on gastric secretin induced by cinchophen were investigated on dogs with total gastric pouch, and it was found out that Antrenyl, Pro-banthine and Tropin all strongly inhibited such secretion, but that a little larger doses than that of insulin were necessary ; effect of Banthine was rather inferior to the above. These anticholinergic drugs were not considered to exert any inhibitory action on the hypothalamic-pituitary-adrenocortical system, which is related to the gastric secretion by cinchophen, but to inhibit the release of the secretory substance into the stomach by acting on its glandular cells. Regitin and chlorpromazine did not show any inhibitory acticn on gastric secretion by cinchophen.Combined administrarion of cinchophen and Tropin for 3 weeks produced ulcer as in controls.

Key concepts: Anticholinergic, Secretin, Gastric secretion, Secretion, Internal medicine, Endocrinology, Anticholinergic agents, Stomach

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EFFECTS OF AUTONOMIC BLOCKING AGENTS ON GASTRIC SECRETION AND ULCERATION INDUCED BY CINCHOPHEN — Research Paper | ScholarLens