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Synthesis of a Glycogen Synthase Kinase-3 Inhibitor

Nicholas A. Magnus, Christopher P. Ley, Pamela M. Pollock, James P. Wepsiec

Open publisher page 2 citations

Abstract

Significance Glycogen synthase kinase-3 (GSK-3) is involved in signaling from the insulin receptor and inhibitors of it are expected to lower plasma glucose similar to insulin. It is under development for the treatment of type 2 diabetes. The target bisarylmaleimide was synthesized in seven steps in 33% overall yield from 5-fluoroindole ( A ).

About this research paper

What this paper is about

Significance Glycogen synthase kinase-3 (GSK-3) is involved in signaling from the insulin receptor and inhibitors of it are expected to lower plasma glucose similar to insulin. It is under development for the treatment of type 2 diabetes. The target bisarylmaleimide was synthesized in seven steps in 33% overall yield from 5-fluoroindole ( A ).

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OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Method / approach

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Available abstract

Significance Glycogen synthase kinase-3 (GSK-3) is involved in signaling from the insulin receptor and inhibitors of it are expected to lower plasma glucose similar to insulin. It is under development for the treatment of type 2 diabetes. The target bisarylmaleimide was synthesized in seven steps in 33% overall yield from 5-fluoroindole ( A ).

Key concepts: GSK-3, Glycogen synthase, Chemistry, Glycogen, Insulin receptor, Insulin, GSK3B, Biochemistry

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