1969•Agricultural and Biological ChemistryOpen access

Studies on Biologically Active Substances Formed by Bacilli

SHIGERU AONUMA, TSUTOMU MIMURA, Jeman Kim, Hiroko Akamatsu, Kihachi Saito

Abstract

The products of several Bacillus strains were investigated on rabbit serum calcium decreasing, oxytocic and toad heart function promoting activities. These products were obtained from the clear supernatant fluid of the culture medium after the cells were removed by centrifugation. For the production of rabbit serum calcium decreasing substance, Bacillus subtilis K and Bacillus natto No. 8 were found to be usefull, Bacillus megaterium KM, Bacillus cereus var. mycoides and Bacillus subtilis K produced oxytocic principle. Bacillus subtilis K, Bacillus brevis and Bacillus megaterium KM also produced toad heart function promoting factor.

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Key concepts: Bacillus megaterium, Bacillus subtilis, Bacillus cereus, Bacilli, Chemistry, Bacillus (shape), Microbiology, Calcium