1989•The Journal of AntibioticsOpen access

Ramoplanin (A-16686), a new glycolipodepsipeptide antibiotic. IV. Complete sequence determination by homonuclear 2D NMR spectroscopy.

J. K. KETTENRING, Romeo Ciabatti, Geoffrey C. Winters, Giovanni Tamborini, BRUNO CAVALLERI

Abstract

Homonuclear 2D NMR spectroscopy double quantum filter correlation spectroscopy (DQF-COSY), relayed-COSY, nuclear Overhauser enhancement spectroscopy (NOESY), and DQF-relayed-NOESY) allowed the complete determination of the core depsipeptide of antibiotic ramoplanin (A-16686). In particular, the DQF-relayed-NOESY experiments were essential in assigning the single signals close to the diagonal.

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Available abstract

Key concepts: Two-dimensional nuclear magnetic resonance spectroscopy, Homonuclear molecule, Nuclear magnetic resonance spectroscopy, Nuclear Overhauser effect, Spectroscopy, Chemistry, Pulse sequence, Stereochemistry