1993•The Journal of AntibioticsOpen access

TAN-1057 A-D, new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus. Taxonomy, fermentation and biological activity.

NOZOMI KATAYAMA, Shoji Fukusumi, Yasunori Funabashi, T Iwahi, Hideo Onο

Abstract

Two Gram-negative bacteria were found to produce the new antibacterial antibiotics TAN-1057 A, B, C and D. The producing bacteria were characterized and designated as Flexibacter sp. PK-74 and PK-176. These antibiotics were active against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. TAN-1057 A inhibited protein biosynthesis in Escherichia coli and S. aureus. It showed excellent protective effects against an experimental methicillin-resistant S. aureus infection in mice.

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Key concepts: Staphylococcus aureus, Antibiotics, Microbiology, Methicillin-resistant Staphylococcus aureus, Antibacterial activity, Fermentation, Antibacterial agent, Chemistry