Chlorotrimethylsilane Mediated Preparation of Allylated Gelatin.

In order to develop biocompatible materials, many workers have studied on conjugation of gelatin with synthetic polymers, for example, by graft polymerization of vinyl monomers onto gelatin in aqueous solution or by dry-blending of gelatin powder with synthetic polymers.So, it was tried to esterify carboxyl groups of the aspartic and glu tamic acid residues of gelatin with a functional alcohol, and a reactive gelatin modified with allyl ester groups was newly obtained by chlorotrimethylsilane mediated reaction of gelatin and allyl alcohol. The degree of esterification was found to be determined by the 1HNMR spectroscopy.The resulting allylated gelatin wa s proven to cause graft polymerization through its allyl groups with styrene monomer by the action of radical initiator in an organic solvent to result in a gelatin/synthetic polymer conjugate.