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Experimental lung cancer induced in rabbits by intrabronchial application of 20-methylcholant hrene.

Hideo Nakajima, Kenkichi Oho, Ming Chin Chow, Eishin Lin, Masanori Tachibana, Makoto Tawara, Takashi Kawauchi, Ryuta Amemiya, Yoshihiro Hayata

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Abstract

大型動物である家兎に20-MCの経気道的投与法で高率に肺癌を作成する事に成功した. 腫瘍は1.5cm×2.0cmから4.5cm×6.0cmの孤立結節が7例, 3.0cm×4.5cm範囲の浸潤性増殖が1例, 多発結節1生が1例である. その組織型は扁平上皮癌6例, 腺癌3例で未分化癌の発生はなかった. 発生部位はいずれも末梢気管支からのものであった. 又全例に気管, 気管支, 気管側リンパ節に転移を認め, 数例に胸壁, 腎臓等にも転移を認めたものもあった.

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Key concepts: Lung cancer, Medicine, Lung, Cancer, Oncology, Internal medicine, Pathology