1959•Experimental Biology and MedicineRequires access

Some Pharmacological Observations on Tranylcypromine (SKF trans-385); A Potent Inhibitor of Monoamine Oxidase.

Ralph E. Tedeschi, David H. Tedeschi, P. L. Ames, Leonard Cook, Paul A. Mattis, Edwin J. Fellows

Abstract

Treatment of rabbits with tranylcypromine followed by the injection of reserpine produces central nervous system stimulation and a marked rise in rectal temperature. The effects produced by tranylcypromine are assumed to reflect the activity of this agent as an inhibitor of monoamine oxidase.

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Key concepts: Tranylcypromine, Monoamine oxidase inhibitor, Reserpine, Monoamine oxidase, Pharmacology, Stimulation, Chemistry, Nialamide