1958•Experimental Biology and MedicineRequires access
Inhibition of Dihydrofolic Reductase by Aminopterin and Amethopterin.
Mary Osborn, M. Freeman, F.M. Huennekens
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Abstract
The enzyme, dihydrofolic reductase, which catalyzes the TPNH-linked reduction of dihydrofolic acid to tetrahydrofolic acid, is inhibited non-competitively by the folic acid antagonists, Aminopterin and Amethopterin. Values of 1 × 10 -9 M and 2.3 × 10 -9 M were obtained for the inhibitor constants (K I ) of Aminopterin and Amethopterin, respectively.