1990New England Journal of MedicineRequires access

Early Management of Shock and Prophylaxis of Acute Renal Failure in Traumatic Rhabdomyolysis

Jane F. Desforges, Ori S. Better, Jay H. Stein

Open publisher page 598 citations

Abstract

SEISMIC catastrophes leave in their wake survivors trapped under the rubble who suffer from extensive muscle damage and its devastating sequelae of hemodynamic and metabolic disturbances and acute renal failure.1 We review here the pathogenesis of shock and acute renal failure associated with traumatic rhabdomyolysis and suggest guidelines for the early management of shock and the prophylaxis of acute renal failure due to the crush syndrome.Rhabdomyolysis, myoglobinuria, and renal failure have been known to follow massive crush injury.2 3 4 5 6 Indeed, it is now 50 years after the classic description of the crush syndrome in patients injured during the bombing of . . .

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SEISMIC catastrophes leave in their wake survivors trapped under the rubble who suffer from extensive muscle damage and its devastating sequelae of hemodynamic and metabolic disturbances and acute renal failure.1 We review here the pathogenesis of shock and acute renal failure associated with traumatic rhabdomyolysis and suggest guidelines for the early management of shock and the prophylaxis of acute renal failure due to the crush syndrome.Rhabdomyolysis, myoglobinuria, and renal failure have been known to follow massive crush injury.2 3 4 5 6 Indeed, it is now 50 years after the classic description of the crush syndrome in patients injured during the bombing of . . .

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Available abstract

SEISMIC catastrophes leave in their wake survivors trapped under the rubble who suffer from extensive muscle damage and its devastating sequelae of hemodynamic and metabolic disturbances and acute renal failure.1 We review here the pathogenesis of shock and acute renal failure associated with traumatic rhabdomyolysis and suggest guidelines for the early management of shock and the prophylaxis of acute renal failure due to the crush syndrome.Rhabdomyolysis, myoglobinuria, and renal failure have been known to follow massive crush injury.2 3 4 5 6 Indeed, it is now 50 years after the classic description of the crush syndrome in patients injured during the bombing of . . .

Key concepts: Rhabdomyolysis, Medicine, Crush syndrome, Myoglobinuria, Crush injury, Shock (circulatory), Intensive care medicine, Acute kidney injury

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