1974•Experimental Biology and MedicineRequires access
Effect of Digitoxin on Hypoxia-Produced Cardiac Hypertrophy in Rats
Edward J. Van Liere, Shelly K. Roberts, D. A. Sizemore, J. Clifford Stickney
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Abstract
Administration of digitoxin prevented hypertrophy of the left ventricle of the rat during exposure to hypoxia. The right ventricle was not affected by the drug and showed a significant degree of hypertrophy. Presumably digitoxin greatly lessened left ventricular hypertrophy by increasing the capacity of cardiac muscle to do work.