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Modeling The Metastasis Promoting Tumor Microenvironment Using Extracellular Matrix Three Dimensional Culture

Hong T. Nguyen, Cui Li, Stephen P. Kantrow, Gilbert F. Morris, Deborah E. Sullivan, Bin Shan

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Abstract

Rationale: The tumor microenvironment is rich in growth factors and extracellular matrix (ECM), such as TGF-b1 and type I collagen (Col 1), which promote cancer metastasis. Conventional two-dimensional (2-D) culture cannot faithfully recapitulate the tumor microenvironment. Three dimensional (3-D) culture of malignant epithelial cells in laminin rich ECM (lrECM 3-D) more faithfully mimics the tumor microenvironment.

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What this paper is about

Rationale: The tumor microenvironment is rich in growth factors and extracellular matrix (ECM), such as TGF-b1 and type I collagen (Col 1), which promote cancer metastasis. Conventional two-dimensional (2-D) culture cannot faithfully recapitulate the tumor microenvironment. Three dimensional (3-D) culture of malignant epithelial cells in laminin rich ECM (lrECM 3-D) more faithfully mimics the tumor microenvironment.

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Available abstract

Rationale: The tumor microenvironment is rich in growth factors and extracellular matrix (ECM), such as TGF-b1 and type I collagen (Col 1), which promote cancer metastasis. Conventional two-dimensional (2-D) culture cannot faithfully recapitulate the tumor microenvironment. Three dimensional (3-D) culture of malignant epithelial cells in laminin rich ECM (lrECM 3-D) more faithfully mimics the tumor microenvironment.

Key concepts: Extracellular matrix, Tumor microenvironment, Laminin, Metastasis, Cell biology, Chemistry, Matrix (chemical analysis), Cancer research

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