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Immunopathological analysis of recurrent rheumatoid nodules.

Yuko Nakajima, Kazuto Sato, Nobuyuki Miyasaka, Makoto Goto, Kusuki Nishioka

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Abstract

Recurrent rheumatoid nodules from the patient with rheumatoid arthritis were investigated. Immunohistochemical analysis of the early rheumatoid nodules suggested that immune responses among CD4 positive T cells and HLA-DR positive mesenchymal cells might be involved in the development of the nodules. Furthermore, interleukin-1 activity were detected in the culture supernatant of the nodules. The role of cytokines in the rheumatoid nodules should be further investigated.

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Recurrent rheumatoid nodules from the patient with rheumatoid arthritis were investigated. Immunohistochemical analysis of the early rheumatoid nodules suggested that immune responses among CD4 positive T cells and HLA-DR positive mesenchymal cells might be involved in the development of the nodules. Furthermore, interleukin-1 activity were detected in the culture supernatant of the nodules. The role of cytokines in the rheumatoid nodules should be further investigated.

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Available abstract

Recurrent rheumatoid nodules from the patient with rheumatoid arthritis were investigated. Immunohistochemical analysis of the early rheumatoid nodules suggested that immune responses among CD4 positive T cells and HLA-DR positive mesenchymal cells might be involved in the development of the nodules. Furthermore, interleukin-1 activity were detected in the culture supernatant of the nodules. The role of cytokines in the rheumatoid nodules should be further investigated.

Key concepts: Rheumatoid nodule, Rheumatoid arthritis, Immunohistochemistry, Medicine, Immune system, Immunology, Pathology

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Immunopathological analysis of recurrent rheumatoid nodules. — Research Paper | ScholarLens