Antimicrobial Activity of Antibiotic Producing Streptomyces macrosporus

The aim of the present study was to isolate and to identify the actinomycetes having antimicrobial activity.Actinomycetes strain isolated from soil samples collected at the Coimbatore region, Tamilnadu, India.Actinomycetes were isolated by spread plate technique and screening was done by parallel streak & agar well diffusion method.Upon primary screening by parallel streak method out of 180 actinomycetes isolates around 25 isolates showed antimicrobial activity against test organisms.On secondary screening out of 25 isolates, 9 isolates showed activity.According to antimicrobial activity and spectrum broadness strain 7 was selected for further study.Based on the morphological, physiological, biochemical and phylogenetic characterization the strain 7 was identified as Streptomyces macrosporus.In conclusion the isolated strain has broad spectrum of antimicrobial activity against the test organisms.