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In vivo Release of Histamine from Rabbit Blood by Reserpine

T. Phillip Waalkes, Herbert Weissbach

Abstract

Intravenous reserpine in rabbits has been demonstrated by chemical means to release histamine from whole blood. 1. The minimal histamine levels were reached in one to 2 days with complete recovery to control values in 5 to 7 days. 2. Simultaneous serotonin determinations, revealed that the rate and degree of liberation, and the recovery of both histamine and serotonin were very similar. 3. Platelets, isolated 24 hours after reserpine, showed a marked reduction in both histamine and serotonin compared to control platelets.

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Key concepts: Reserpine, Histamine, Serotonin, Liberation, Platelet, In vivo, Chemistry, Endocrinology