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Effects of roxithromycin on neutrophil chemotaxis and phagocytosis in vitro.

Hirohiko Akamatsu, Hiroko Sasaki, Yoko Matoba, Shuhei Ri, Setsuko Nishijima, Yasuo Asada

Abstract

The effects of roxithromycin, a new orally semisynthetic macrolide, were investigated on human neutrophil chemotaxis and phagocytosis in vitro. The agent markedly stimulated neutrophil chemotaxis and phagocytosis in a dose-dependent manner. These results may indicate that roxith-romycin potentiates the activation of neutrophils in vivo.

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Key concepts: Roxithromycin, Phagocytosis, Chemotaxis, In vitro, In vivo, Chemistry, Microbiology, Immunology