1960•Experimental Biology and MedicineRequires access

Norepinephrine Depletion as a Possible Mechanism of Action of Guanethidine a New Hypotensive Agent

Robert Cass, R. Kuntzman, B.B. Brodie

Abstract

Guanethidine (Su-5864), a new hypotensive agent, depletes the norepinephrine level in the heart of rabbits and cats. It is suggested that guanethidine lowers blood pressure by producing chemical sympathectomy through depletion of norepinephrine from peripheral nerve endings.

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Key concepts: Guanethidine, Norepinephrine, Sympathectomy, CATS, Blood pressure, Medicine, Free nerve ending, Sympathetic nerve