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1982•Journal of Pediatric Ophthalmology & StrabismusRequires access

Endodermal Sinus Tumor (Yolk-Sac Carcinoma) of the Orbit

Norman N.K. Katz, Frederick B. Ruymann, Curtis E. Margo, Lou A Popejoy, Francis G. LaPiana

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Abstract

A 15-month-old boy with rapidly progressive proptosis had an unusual malignant germ-cell tumor of the orbit and nasopharynx identified as an endodermal sinus tumor (yolk-sac carcinoma). Endodermal sinus tumors arising in extra gonadal locations are highly malignant and generally lethal. The boy was treated with radiation and three-drug chemotherapy and has survived more than eight years.

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What this paper is about

A 15-month-old boy with rapidly progressive proptosis had an unusual malignant germ-cell tumor of the orbit and nasopharynx identified as an endodermal sinus tumor (yolk-sac carcinoma). Endodermal sinus tumors arising in extra gonadal locations are highly malignant and generally lethal. The boy was treated with radiation and three-drug chemotherapy and has survived more than eight years.

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OpenAlex reports 27 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A 15-month-old boy with rapidly progressive proptosis had an unusual malignant germ-cell tumor of the orbit and nasopharynx identified as an endodermal sinus tumor (yolk-sac carcinoma). Endodermal sinus tumors arising in extra gonadal locations are highly malignant and generally lethal. The boy was treated with radiation and three-drug chemotherapy and has survived more than eight years.

Key concepts: Endodermal sinus tumor, Yolk sac, Medicine, Orbit (dynamics), Chemotherapy, Sinus (botany), Embryonal carcinoma, Carcinoma

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